B-Cell Lymphoma

Title:

B-Cell Lymphoma, Unclassifible, With Features Intermediate between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma: A Review of Reported Cases

Abstract: 

Grey Zone Lymphoma (GZL), with features intermediate between classical Hodgkin lymphoma (cHL) and diffuse large B-cell
lymphoma (DLBCL), is a new entity with limited reported data. A MEDLINE search through July 2013 identifid 39 cases of GZL
and two additional cases were added from our institution. Comparison of complete remission (CR) rates between ABVD and CHOPbased regimens was performed using Fisher’s exact test. The median age of presentation was 33.5 years with a male predominance
(59%), mediastinal involvement (89%), and early stage disease (75%). Patients treated with CHOP-based regimens achieved higher
CR rates compared to initial ABVD-based regimens (80% vs. 0%;p=0.01). The 2-yr OS was 87% with a median OS that was not
reached. Our review indicates this lymphoma subtype to have a high incidence of early stage presentation, mediastinal involvement,
B symptoms and overall better outcomes with CHOP-based regimens. Additional studies are warranted to further study this disease.

Link:

http://www.ommegaonline.com/form/issues/B-Cell-Lymphoma.php

Advances in Medical Teaching

Title:
Advances in Medical Teaching

Abstract:

Medicine is not just a profession, but a preoccupation and an obsession. Teaching medicine is an art and our medical teachers ought to be artists. This art is learnt over the period of time from the real masters and mentors. The learning and teaching need to move together. From the inception of this art, to its current demonstration, it has undergone a total metamorphosis. Thanks to science for unraveling new methods of teaching. 


http://www.ommegaonline.com/form/issues/Advances-in-Medical-Teaching.php

"The Role of Topical Anesthesia in Flexible Nasofibrolaryngoscopy" Is It Necessary?

 "The Role of Topical Anesthesia in Flexible Nasofibrolaryngoscopy" Is It Necessary? | Ommega Online Publishers


The development of Otolaryngology in recent decades has been facilitated by the emergence of flexible nasofibrolaryngoscopy, which has become an essential diagnostic tool for the otolaryngologist. However, their use is not without discomfort to the patient, which is why various topical anesthesia options have been proposed for the development of the technique. Cocaine paste, Co-Phenylcaine forte, lidocaine, and others have been part of preparations proposed to decrease the degree of discomfort when making such exploration. However existing results in the literature differ on the need for its use. That is why in this article we attempt to review the existing scientific evidence at present regarding the use of topical anesthesia during flexible nasofibrolaryngoscopy.



http://www.ommegaonline.com/form/issues/The-Role-of-Topical-Anesthesia-in-Flexible-Nasofibrolaryngoscopy.php

Simple and Sensitive Method for the Simultaneous Estimation of Drotaverine HCL and Aceclofenac Using RP-HPLC

 Simple and Sensitive Method for the Simultaneous Estimation of Drotaverine HCL and Aceclofenac Using RP-HPLC  | Ommega Online Publishers



To develop a simple and sensitive method for the simultaneous estimation of drotaverine HCL (DRH) and aceclofenac (AF) using RP-HPLC. The HPLC separation was achieved on a thermo column (250 mm × 4.6 mm, 5μ) with an isocratic mixture of acetonitrile and 5 mM of ammonium acetate in the ratio of 65:35, pH adjusted to 4.5 at a flow rate of 1.0 ml/min and the detection at 285nm. The method was validated as per ICH guidelines. The retention time for DRH and AF was 3.9 and 5.0 minutes, respectively. The optimized method was linear in the range of 50 - 120 ng/ml and 100 - 700 ng/ml for DRH and AF respectively. The overall recovery of DRH and AF were 99.8 and 99.5 % respectively. The developed sensitive, robust and rugged method as proven reproducibility of the result obtained as an outcome of small deliberate variation in the analytical parameter and the change the operator. 


http://www.ommegaonline.com/form/issues/Simple-and-Sensitive-Method-for-the-Simultaneous-Estimation-of-Drotaverine-HCL-and-Aceclofenac-Using-RP-HPLC.php

Obesity-Related Hormones and Metabolic Risk Factors: A Randomized Trial of Diet plus Either Strength or Aerobic Training versus Diet Alone in Overweight Participants

 Obesity-Related Hormones and Metabolic Risk Factors | Ommega Online Publishers


There is debate about the additive effects of exercise in conjunction with diet to treat obesity, and not much is known about the differential effects of strength versus aerobic training. This randomized controlled trial examined the effects of diet plus strength training, diet plus aerobic training, or diet only on metabolic risk factors associated with obesity. Eighty-one overweight and obese participants completed the 8-week intervention. All participants received an energy-restrictive formula diet with an energy content based on 70% of measured resting metabolic rate (RMR). Participants assigned to an exercise group trained 3 days/week under supervision. Anthropometrics and fasting hormones were assessed pre- and post-intervention. Mean weight loss (8.5± 4.3kg SD) did not differ between groups nor did reductions in BMI or body fat, although the diet plus strength training group showed marginally greater lean mass retention. There were significant improvements in the values and number of metabolic syndrome risk factors, and decreases in insulin concentrations and insulin resistance, which did not vary between groups. For men, testosterone increased significantly more in the diet plus aerobic training as compared to the other groups. As compared to diet alone, the addition of strength or aerobic training did not improve changes in BMI, body fat or metabolic risk factors although the diet plus strength training group showed a trend toward preservation of lean mass, and the diet plus aerobic group in men resulted in increased testosterone concentrations. 


 http://www.ommegaonline.com/form/issues/Obesity-Related-Hormones-and-Metabolic-Risk-Factors.php

High Blood Pressures

 High Blood Pressures | Ommega Online Publishers


Case Stem (one to two paragraphs on pertinent patient and scenario information-this should be the stem for the learner and should include location, physician/help availability, family present, etc.)
60 year old male with no past medical or surgical history presented to the Emergency Room with sudden onset dyspnea and palpitations^[1,2]. For the past 2 weeks, he had been experiencing include intermittent headaches, palpitations, anxiety, and occasional shortness of breath on exertion, which is what brought him to the hospital. This morning, his wife noted increased anxiety leading to “he can’t catch his breath.” Work up includes an Electrocardiogram, cardiac enzymes, chest x-ray, stress test, and transthoracic echocardiography, all of which were normal. Incidentally, a abdominal Computerized tomography (CT) scan was performed, and an acute appendicitis could not be ruled out, so he was sent to the Operating Room to do a diagnostic laparoscopy and appendectomy. Background and briefing information for Facilitator/coordinator's eyes only In the ER, his blood pressure ranged from noninvasive systolic 140-280 millimeters mercury over diastolic 30-150 millimeters mercury, so a CT (computerized tomography) abdomen showed a 6-centimeter round mass retroperitoneally on the right adrenal gland suggesting pheochromocytoma[4,5], but this was missed initially as it only showed a possible acute appendicitis. Serum epinephrine was 18.6 nanogram/milliliter (normal: 0.01-0.18 nanogram/milliliter), norepinephrine 24.2 nanogram/milliliter (normal: 0.06-0.45 nanogram/milliliter), and dopamine 4.8 nanogram/milliliter (normal 0-0.09 nanogram/milliliter). No metaiodobenzylguanidine (MIGB) scan performed because of acute renal failure. 


 http://www.ommegaonline.com/form/issues/High-Blood-Pressures.php

Fructose Intake and Circulating Triglycerides: An Examination of the Role of APOC 3

 Fructose Intake and Circulating Triglycerides: An Examination of the Role of APOC 3  | Ommega Online Publishers




Fructose consumption can lead to marked increases in plasma triglycerides in both humans and laboratory animals. We have observed that overnight access to a 16% fructose solution can promote hypertriglyceridemia in rats. Several investigators have suggested that APOC 3 may be implicated in promoting fructose-induced hypertriglyceridemia. We have examined the role of APOC 3 in liver and blood taken from rats that had been given access to a fructose solution overnight as a supplement to standard laboratory chow. Hepatic APOC3 mRNA expression from fructose alone resulted in a 14 % reduction compared to control. Interestingly, hepatic APOC3 expression was increased by about 250% in sucrose, high fructose corn syrup and glucose groups. The serum protein levels of APOC3 did not differ across groups. Contrary to our hypothesis, these results indicate that glucose containing sugars increased hepatic APOC3 mRNA expression but no sugar was capable of increasing the serum protein level.



http://www.ommegaonline.com/form/issues/Fructose-Intake-and-Circulating-Triglycerides.php