B-Cell Lymphoma

Title:

B-Cell Lymphoma, Unclassifible, With Features Intermediate between Diffuse Large B-Cell Lymphoma and Classical Hodgkin Lymphoma: A Review of Reported Cases

Abstract: 

Grey Zone Lymphoma (GZL), with features intermediate between classical Hodgkin lymphoma (cHL) and diffuse large B-cell
lymphoma (DLBCL), is a new entity with limited reported data. A MEDLINE search through July 2013 identifid 39 cases of GZL
and two additional cases were added from our institution. Comparison of complete remission (CR) rates between ABVD and CHOPbased regimens was performed using Fisher’s exact test. The median age of presentation was 33.5 years with a male predominance
(59%), mediastinal involvement (89%), and early stage disease (75%). Patients treated with CHOP-based regimens achieved higher
CR rates compared to initial ABVD-based regimens (80% vs. 0%;p=0.01). The 2-yr OS was 87% with a median OS that was not
reached. Our review indicates this lymphoma subtype to have a high incidence of early stage presentation, mediastinal involvement,
B symptoms and overall better outcomes with CHOP-based regimens. Additional studies are warranted to further study this disease.

Link:

http://www.ommegaonline.com/form/issues/B-Cell-Lymphoma.php