Sensitive Method for the Simultaneous Estimation of Drotaverine HCL and Aceclofenac Using RP-HPLC

Simple and Sensitive Method for the Simultaneous Estimation of Drotaverine HCL and Aceclofenac Using RP-HPLC

 

Abstract :
 
To develop a simple and sensitive method for the simultaneous estimation of drotaverine HCL (DRH) and aceclofenac (AF) using RP-HPLC. The HPLC separation was achieved on a thermo column (250 mm × 4.6 mm, 5μ) with an isocratic mixture of acetonitrile and 5 mM of ammonium acetate in the ratio of 65:35, pH adjusted to 4.5 at a flow rate of 1.0 ml/min and the detection at 285nm. The method was validated as per ICH guidelines. The retention time for DRH and AF was 3.9 and 5.0 minutes, respectively. The optimized method was linear in the range of 50 - 120 ng/ml and 100 - 700 ng/ml for DRH and AF respectively. The overall recovery of DRH and AF were 99.8 and 99.5 % respectively. The developed sensitive, robust and rugged method as proven reproducibility of the result obtained as an outcome of small deliberate variation in the analytical parameter and the change the operator. 

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Asymmetry of Symptoms in Multiple System Atrophy

Asymmetry of Symptoms and Signs in Multiple System Atrophy

Abstract :


It has been widely recognized that some of the symptoms and signs of multiple system atrophy (MSA) emerge with laterality, but only a few studies have evaluated this issue comprehensively. Small-scale case reports that have been published thus far suggest that laterality in MSA is a rather rare finding.
In order to examine the prevalence and characteristics of laterality in symptoms and signs in MSA, we retrospectively investigated the records of 155 MSA patients. Among all the patients, 39% had episodes that suggested the presence of laterality in their illness history.
The MSA with predominant parkinsonism (MSA-P) patients presented with more episodes of laterality than the MSA with cerebellar features (MSA-C) patients. Among the episodes, laterality was more frequent in parkinsonism than for the cerebellar symptoms.Interestingly, these symptoms were more prevalent at the left side of the body. Laterality in the cerebellar signs was present in 63% of the MSA-C patients and laterality in parkinsonism was exhibited by 64% of the MSA-P patients. Interestingly, cerebellar signs, parkinsonism, and Horner's sign were all observed predominantly at the left side.
Thus, we concluded that a significant number of MSA patients present with laterality in both symptoms and signs and that more interestingly, these are predominantly observed at the left side.
   
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Neurology and Brain Disorders

International Journal of Neurology and Brain Disorders

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Ommega Journals is peer reviewed, multidisciplinary Open Access journal, written by internationally renowned clinical academics and researchers and researchers which aims to deliver quality work and access to its readers across various fields of science.

     IJNBD (International Journal of Neurology & Brain Disorders) is the life line of medical sciences that deals with the disorders of the nervous system. Diseases involving the central and peripheral nervous systems, somatic nervous systems are dealt with the treatment of neurology. Some of the commonly encountered conditions treated by neurologists are headaches, neuropathy, stroke, dementia, seizures and epilepsy, Alzheimers disease, Attention deficit or hyperactivity disorder, Parkinsons disease, multiple sclerosis, head trauma, sleep disorders, neuromuscular diseases, and various infections and tumors of the nervous system.
     

     Neurology, being a branch of medicine, differs from neuroscience, which is the scientific study of the nervous system in all of its aspects. Some neurologists also develop interests in subfields, such as dementia, chronic pain management, multiple sclerosis, movement disorders, headaches, epilepsy, sleep disorders, stroke, or neuromuscular diseases. Ommega Journals aims to provide the most complete and reliable source of information on the latest discoveries and current developments. OJN is available online for free access to all. This journal is open to share knowledge and help others focused on the latest advancements


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Journal of Anesthesia and Surgery

Journal of Anesthesia and Surgery

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Ommega Journals of Anesthesia and Surgery are peer reviewed, multidisciplinary Open Access journal, written by internationally renowned clinical academics and researchers and researchers which aims to deliver quality work and access to its readers across various fields of science.

     Ommega Journals of Anesthesia and Surgery publishes original articles, review articles, special articles, brief reports, clinical reports, short communications, letters to the editor’s anesthesia and its field of current advances in an anesthesia and related sciences. Surgery provides information on surgical sciences and practices. Surgery discusses on current experimental research in all areas of surgery and its related fields like abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery.

     Ommega Journals of Anesthesia and Surgery follows the Creative Commons Attribution License and scholars open access publishing policies, readers can freely access the published articles through online with unique Digital Objective Identifier (DOI) provided by Cross Ref.

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Nanotechnology and Materials Science

Journal of Nanotechnology and Materials Science

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Journal of Nanotechnology and Materials Science is a peer reviewed, multidisciplinary Open Access journal, written by internationally renowned clinical academics and researchers which aims to deliver quality work and access to its readers across various fields of science.

Nanotechnology is the study and application of things that are extremely small and can be used across all the fields of science , such as  surface science, organic chemistry, molecular biology, semiconductor physics, micro fabrication, etc. Nanotechnology covers wide varieties of topics such as molecular nanotechnology, nanosensors, nanoparticles, nano-electronics, nanodevices, nanorobotics etc. With significant developments in the fields of nanoscience and nanotechnology. In recent years, materials science is becoming more widely known as a specific field of science and engineering. Materials science is commonly known as materials engineering.

Journal of Nanotechnology and Materials Science follows the Creative Commons Attribution License and scholars open access publishing policies, readers can freely access the published articles through online with unique Digital Objective Identifier (DOI) provided by Cross Ref.

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Journal of Environment and Biotechnology

International Journal of Environment and Biotechnology

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International Journal of Environment & Biotechnology - Open Access (IJEB) is an international standard peer reviewed open access research publication. This journal offers a platform for articles from the interface of environmental issues and biotechnology. IJEB publishes scientific articles to provide its members and readers a gateway to the scientific community in accordance with ethical standards of peer reviewed publication.

Preference is given to manuscripts which identifies and describes environmental problems, their possible impact on ecology, human health and biotechnological processes aiming at reduction or remediation of environmental problems.

International Journal of Environment & Biotechnology follows the Creative Commons Attribution License and scholars open access publishing policies, readers can freely access the published articles through online with unique Digital Objective Identifier (DOI) provided by Cross Ref.

 The scope includes publications connected to any of the following areas:

 • toxicity of chemical compounds

 • environmental issues realted to industry and agriculture

 • biological treatment of sewage and wastes

 • industrial biotechnology and microbiology

 • biofuels for transportation

 • biorefineries

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Journal of Heart and Cardiology

Journal of Heart and Cardiology

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Journal of Heart & Cardiology is an international peer- reviewed open access Journal which accesses the quality of articles. The board of scholarly reviews the subject area of this Journal.

 Journal of Heart & Cardiology Publishes original research articles, reviews, commentaries, reports, editorials, letters and short communications on all aspects of cardiology. Cardiology covers the vast area of research on cardiovascular disorders,  Cardiac Electrophysiology, Echocardiography, Interventional Cardiology, Aorta, Arterial Thrombosis, Vasculitides, Embolism, Varicose Veins, Nuclear Cardiology, Vasospastic Disorders, Venous Thrombosis, Chronic Venous Insufficiency, etc..

Journal of Heart & Cardiology follows the Creative Commons Attribution License and scholars open access publishing policies, readers can freely access the published articles through online with unique Digital Objective Identifier (DOI) provided by Cross Ref.

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Pharmaceutical Sciences and Drug Designing

Journal of Pharmaceutical Sciences and Drug Designing

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Journal of Pharmaceutical Sciences & Drug Designing are peer reviewed, multidisciplinary Open Access journal, written by internationally renowned clinical academics and researchers and researchers which aims to deliver quality work and access to its readers across various fields of science.

     Journal publishes original articles, review articles, special issue articles, and editorial articles in all aspects of Pharmaceutical Sciences includes Pharmacology, pharmacognosy, medicinal chemistry, pharmaceutics and drug delivery, pharmaceutical analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacogenomics, Cell Biology, microbiology, molecular and clinical pharmacology, Genomics and Proteomics, Biopharmaceutics and Drug disposition, drugs from natural sources, drug design, drug delivery, drug discovery etc.

     Journal of Pharmaceutical Sciences & Drug Designing follows the Creative Commons Attribution License and scholars open access publishing policies, readers can freely access the published articles through online with unique Digital Objective Identifier (DOI) provided by Cross Ref.

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